Bernhard Gleich, Thomas Weyh, Bernhard Wolf
Magnetic Drug Targeting: an analytical model for the influence of blood properties on particle trajectories
Appl. Rheol. 18:5 (2008) 52023 (7 pages)Abstract: Investigations on the behaviour of superparamagnetic nanoparticles under the influence of a high gradient magnetic field in the vascular system is required for a better under-standing of magnetic drug targeting. The influence on the particle transport of the non-Newtonian and Newtonian properties of blood as well as the influence of the heart rate was therefore studied. An analytical model was developed and the calculation of particle trajectories is presented and evaluated.The results show that the non-Newtonian properties of the blood have a positive influence on the number of retended nanoparticles. The calculations also showed that the number of retained nanoparticles was lower in oscillatory flow profile than in steady flow. The influence of the heart rate can be neglected for Womersley numbers smaller than 1.5. © 2008 Applied Rheology.
DOI 10.3933/ApplRheol-18-52023
-- full text PDF
available for subscribers --
-- open access PDF extractavailable for non-subscribers --
You have no password-free access to Applied Rheology Online. If you are a subscriber, enter login details below. For password-free access, we need your IP address. Sample manuscripts for free download can be found here ►
Forgotten your login details? Send an email with subject "AR login" to login@appliedrheology.org
Purchase this article for 20 € ? ►
Appl Rheol 18 (2008) issues:
© Applied Rheology 2018