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Premanarayani Menon, Yin Yin Teo, Misni Misran
Effect of diethylaminoethyl-dextran coated liposomes on the rheological properties of carbopol gel
Appl. Rheol. 28:6 (2018) 62616 (6 pages)
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Liposomal gel has played an important role in administration of drugs via topical and transdermal routes. Incorporation of
liposome into gel not only has overcome the liquid nature of liposomal dispersion but also helped to preserve the original
structure of liposome. In this study, we formulated a liposomal gel consisting of Carbopol gel and a diethylaminoethyl dextran
(DEAE-DX) coated liposome. The effect of coated and non-coated liposomes on the rheological properties of Carbopol gel was
investigated. The rheological results indicated that incorporation of liposomes into Carbopol gel modified the viscoelastic and
flow behaviour of the gel significantly. Apart from that, liposomal gel consisting of DEAE-DX coated liposomes exhibited more
solid-like behavior compared to the non-coated liposomal gel. Incorporation of DEAE-DX coated liposomes increased the yield
stress of liposomal gel compared to non-coated liposomes. This supports the findings obtained from the amplitude and frequency
tests whereby addition of DEAE-DX enhanced the rigidity of the gel so that the resultant gel was more resistant to
flow.
► Cite this publication as follows:
Menon P, Teo YY, Misran M: Effect of diethylaminoethyl-dextran coated liposomes on the rheological properties of carbopol gel, Appl. Rheol. 28 (2018) 62616.
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