2011-01-19
10:15 at HCI J 574

Statistical Mechanics of Sequence-Dependent Coarse Grain Models of DNA

John H. Maddocks

EPFL

DNA is a rather stiff polymer, where it is believed that nonuniformity due to the specific sequence along the molecule is biologically important. I will describe ongoing work in my group on extracting constitutive relations for coarse grain models of DNA from fully atomistic Molecular Dynamics simulations, along with the analysis necessary to model in vitro experimental data to assess the accuracy of the constitutive relations.